学生无码

杜蔚

职 称: 副教授

学 历: 博士

电子邮件: [email protected]

研究方向: 1. 小分子探针设计 2. 抗癌前药设计 3. 光学成像分析

教育工作经历 (Education and working experiences)

2020.08至今 学生无码

2013.09-2020.07 中国科学技术大学,理学博士,导师:梁高林教授

2009.09-2013.06 四川大学,理学学士

科研简介 (Scientific research)

围绕癌症、肝损伤等疾病的诊断与治疗进行光学成像分析、小分子探针设计与小分子前药设计。目前已发在Angew. Chem. Int. Ed., Adv. Funct. Mater., ACS Nano等期刊上发表论文20余篇,其中第一作者和通讯作者论文10余篇。申请并授权国家发明专利1项(排名第二)。目前主持国家自然科学基金、省级自然科学基金和校科研启动项目各1项,作为骨干成员参与国家级项目多项。

科研项目 (Scientific research projects)

国家自然科学基金联合基金项目(U24A20509,2025-2028),学生无码 负责人

国家自然科学基金青年科学基金项目(22204021,2023-2025),主持

福建省自然科学基金面上项目(2022J01068,2022-2025),主持

学生无码 科研启动基金,主持

代表性论文 (Representative papers)

1. Shenggan XiaoLiting ZhengZhongxiang ChenQingqing LiShi Gao,*Wei Du,* and Jibin Song*. Chemodynamic Therapeutic Nanoplatform with Activatable NIR-II Ratiometric Fluorescence for Self-Evaluating Fenton Reactivity.J. Med. Chem.2025, 68, 14895−14906.

2. Qingqing Li, Qing Chen, Shenggan Xiao, Shuhan Wang, Xiaoguang Ge, Qian Wang, Liting Zheng, Qiaoqiao Wei,Wei Du, Wenbin Shen, Ying Wu, and Jibin Song*. A Salidroside-Based Radiosensitizer Regulates the Nrf2/ROS Pathway for X-Ray Activated Synergistic Cancer Precise Therapy.Adv. Mater.2025, 37, 2413226.

3. Zhicun Yao, Fei Xu, Rongrong Wu, Xian Wang, Mao Guo, Shuhan Wang, Kaiqiong Yang,Wei Du,* and Jibin Song*. Dual-Locked Probe with Activatable Sonoafterglow Luminescence for Precise Imaging of MET-Induced Liver Injury.Anal. Chem.2024, 96, 15031−15041.

4. Qingqing Li, Shenggan Xiao, Xiaoguang Ge, Liting Zheng, Ying Wu,Wei Du, Lanlan Chen,* Huanghao Yang,* and Jibin Song*. Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo.Angew. Chem. Int. Ed.2024, 63, e202408792.

5. Aihua Liao,Wei Du*, and Huanghao Yang*. The Inverse Electron Demand Diels-Alder Reaction Between Tetrazine and Trans-Cyclooctene for Pretargeted Bioimaging Applications.Analysis & Sensing2024, 4, e202300053.

6. Qian Li1, Zhongxiang Chen1, Lichao Su, Ying Wu,Wei Du*, Jibin Song *. Constructing Turn-on Bioluminescent Probes for Real-time Imaging of Reactive Oxygen Species during Cisplatin Chemotherapy.Biosens. Bioelectron.2022, 216, 114632.

7. Rongrong Wu,§Zhongxiang Chen,§Hongqi Huo,§Lanlan Chen,* Lichao Su, Xuan Zhang, Ying Wu, Zhicun Yao, Shenggan Xiao,Wei Du,* and Jibin Song*. Ratiometric Detection of H2S in Liver Injury by Activated Two-Wavelength Photoacoustic Imaging.Anal. Chem.2022, 94 (30), 10797−10804.

8. Chenchen Wang,Wei Du, Chenfan Wu, Shan Dan, Miao Sun, Tong Zhang, Bin Wang, Yue Yuan*, and Gaolin Liang*. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging.Angew. Chem. Int. Ed.2022, 61, e202114766.

9. Feicheng Bai#,Wei Du#, (co-first author)Xia Liu, Lichao Su, Zhi Li, Tao Chen, Xiaoguang Ge, Qingqing Li, Huanghao Yang, and Jibin Song*. A NO-Responsive Ratiometric Fluorescent Nanoprobe for Monitoring Drug-Induced Liver Injury in the Second Near-Infrared Window,Anal. Chem.2021, 93, 15279–15287.

10. Hongjuan Feng,# Qinrui Fu,#Wei Du,#(co-first author) Rong Zhu, Xiaoguang Ge, Chenlu Wang, Qingqing Li, Lichao Su, Huanghao Yang, and Jibin Song*. Quantitative Assessment of Copper(II) in Wilson’s Disease Based on Photoacoustic Imaging and Ratiometric Surface-Enhanced Raman Scattering.ACS Nano2021, 15, 3402-3414.

11. Chenchen Wang,||Wei Du,||(co-first author) Tong Zhang, and Gaolin Liang*. A Bioluminescent Probe for Simultaneously Imaging Esterase and Histone Deacetylase Activity in a Tumor.Anal. Chem.2020, 92, 15275-15279.

12. Jihua Chen,#Yinchu Ma,#Wei Du,#(co-first author) Tianyue Dai, Yanfang Wang, Wei Jiang, Yifei Wan, Yucai Wang, Gaolin Liang*, and Guangfeng Wang*. Furin-Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy.Adv. Funct. Mater.2020, 30, 2001566.

13. Yanfang Wang,§Wei Du,§(co-first author) Tong Zhang, Yu Zhu, Yanhan Ni, Chenchen Wang, Fatima Maria Sierra Raya, Liwei Zou, Longsheng Wang,* and Gaolin Liang*. A Self-evaluating photothermal therapeutic nanoparticle.ACSNano2020,14, 9585−9593.

14.Wei Du, Yuanyuan Chong, Xiaomu Hu, Yanfang Wang, Yu Zhu, Jihua Chen, Xiaoxia Li, Qun Zhang, Guangfeng Wang,* Jun Jiang,* and Gaolin Liang*. Increasing Photothermal Efficacy by Simultaneous Intra- and Intermolecular Fluorescence Quenching.Adv. Funct. Mater.2020, 30, 1908073.

15.Wei Du, Xiaomu Hu, Weichen Wei, and Gaolin Liang*. Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nano-drug Preparation.Bioconjugate Chem.2018, 29(4), 826-837.

16.Wei Du, Yusi Cui and Gaolin Liang*. Applications of Organic-Inorganic Hybrid Nanoparticles for Cancer Imaging. In book: Hybrid Nanomaterials: Design, Synthesis, and Biomedical Applications, pp.110-155. Edited by Feng Chen and Weibo Cai.CRC press. 2016.(book chapter)

17.Wei Du, Yue Yuan, Lin Wang, Yusi Cui, Hui Wang, Huiqin Xu*, and Gaolin Liang*. Multifunctional Bioconjugate for Cancer Cell-Targeted Theranostics.Bioconjugate Chem., 2015, 26, 2571-2578.

18. Yue Yuan, Lin Wang,Wei Du, Zhanling Ding, Jia Zhang, Tao Han, Linna An, Huafeng Zhang*, and Gaolin Liang*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multi-Drug Resistance.Angew. Chem. Int. Ed.2015, 54, 9700-9704.

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